Figure 2
Chemerin inhibits tumor progression in mouse models of HCC. (a) Kaplan–Meier plot of survival of WT and Rarres2−/− mice implanted with Hepa1-6 cells in an orthotopic HCC model. n=16–18. (b) Representative images of liver tumors and the liver weight. (c) Left, representative images of hematoxylin and eosin (H&E)-stained lung sections. Right, numbers of metastatic nodules counted in a 100X high-power field (HPF). Original magnification, × 100; scale bar, 100 μm. (d) Kaplan–Meier plot of survival of WT mice implanted with Ctrl-Hepa1-6 cells or chemerin-overexpressing Hepa1-6 cells in an orthotopic HCC model. n=12–14. (e) Representative images of liver tumors and the liver weight. Columns and error bars represent mean±s.e.m. (n=12–18 per group). **P<0.01, ***P<0.001. Similar results were obtained from three independent experiments.
