Figure 5
From: Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells
Gene expression analysis of EP-based novel mouse MBG3 models. (a) Unsupervised hierarchical heat map using top 1000 signature genes of murine medulloblastoma. (b) Principal component analysis across murine models and GNPs. (c) Probabilities of subgroup predictions for mouse MB models. Bars represent aggregated prediction probabilities that each mouse model belongs to each MB subgroup, as determined by a random forest classifier that was trained on expression barcodes of human and mouse MB samples. The probabilities that Ptf1a-MYC tumors belong to MBG4 are not significantly higher than Blbp-MYC MBs (P=0.90, n=9, Wilcoxon's rank-sum test). Similarly, Gad2-MYC tumors do not have significantly higher probabilities of belonging to MBG4 compared to Blbp-MYC MBs (P-value=0.48, n=10).
