Table 1 Identity of cerebellar cells targeted by different Cre transgenic mice and incidence of tumors caused by Myc overexpression with loss of Trp53 function

From: Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells

Cre transgenic mouse

Targeted cerebellar cells

Tumor latency

Tumor incidence

Atoh1-CreERa

Granule neural progenitors (Pax6+)

4–14 weeks

n=12/14

Prom1-CreERa

Multipotent cerebellar stem cells (Sox2+)

6–11 weeks

n=8/10

Blbp-Creb

Granule neural progenitors (Pax6+/Atoh1+)

Inhibitory interneurons (Pax2+)

Bergmann glia/multipotent cerebellar stem cells (Sox2+)

Choroid plexus progenitors

5-8 weeks for MBs

3–7 weeks for CPCs

n=14/14 (n=8/14 for MBs, n=6/14 for CPCs)

Atoh1-Creb

Granule neural progenitors (Pax6+)

Choroid plexus progenitors

7 weeks for MBs

4 weeks for CPCs

n=3/3 (n=1/3 for MBs, n=2/3 for CPCs)

Gad2-IRES-Creb

Inhibitory interneurons (Pax2+)

9–13 weeks

n=4/11

Ptf1a-Creb

Inhibitory interneurons (Pax2+)

9–11 weeks

n=3/7

  1. Abbreviations: CPC, choroid plexus carcinoma; MB, medulloblastoma; n, number of animals.
  2. aTamoxifen administration at P0 and P1.
  3. bIn utero electroporation at E13.5.
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