Figure 2

Functional characterization of HMR subtypes. (a) Size and CpG density distribution of common, frequent and t-HMRs in normal B cells. (b) Localization of HMRs defined for B cells, breast and liver tissues within histone mark defined segments of the genome. The distribution is displayed as overlap frequencies. (c) Distribution of common (c-HMRs) and t-HMRs within regulatory regions defined for normal B cells, breast and liver tissues. (d) Enrichment analysis in biological processes for gene promoters harboring t-HMRs (Bonferroni adjusted P-value). (e) Co-occurrence frequency of promoter-associated (proximal) and distal t-HMRs between normal tissue types.