Figure 3
From: A DNA methylation map of human cancer at single base-pair resolution
Genome-scale DNA methylation analysis of 1112 cancer samples reveals cancer-type-specific signatures. (a) Cancer samples analyzed on HumanMethylation450 BeadChip. (b) Unsupervised hierarchical clustering of 1112 cancer samples and 8254 hypermethylated c-HMRs within gene promoters using Jaccard distances and Ward cluster method. Average HMR methylation levels are continuously color-coded from 0% (light blue) to 100% (dark blue). (c) Frequently hypermethylated HMRs in TSG promoters in 1112 cancer samples ordered by type. Average HMR methylation status is categorized as hypermethylated (>33% DNA methylation, dark blue) and hypomethylated (<33% DNA methylation, light blue).
