Figure 4
From: A DNA methylation map of human cancer at single base-pair resolution
HMR subtypes are highly variable in human cancer samples. (a) Size distribution and DNA methylation levels of total HMRs in donor-matched normal colon, primary cancer and metastasis samples. Densities are displayed as low (blue) to high (red). (b) Average DNA methylation levels and standard variation (s.d.) of common (c-HMRs) and t-HMRs in normal tissue (upper panel) and cancer samples (lower panel). (c) DNA methylation structure of c-HMRs in normal and cancer samples. CpG methylation levels are averaged in 4-bp windows over all c-HMRs and displayed ±2-kb flanking the HMR center. (d) DNA methylation profiles of the RASSF1 promoter in normal (broken lines) and cancer samples (solid lines). (e) DNA methylation profiles of the FANCC promoter and a distal c-HMR in normal (upper panel) and cancer samples (lower panel).
