Figure 5 | Oncogene

Figure 5

From: CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A

Figure 5

Cdkn2b inactivation is necessary to make cell encompass senescence induced by oncogenic KRAS. Obvious senescence-associated β-galactosidase (SA-β-GAL) activity was detected in cells infected by KRAS-shTp53, KRAS-shTp53-shCdkn2a, KRAS-shTp53-shCdkn2b, but that was not detected in infected pancreatic cells by KRAS-shTp53-shCdkn2a/b where Cdkn2b and Cdkn2a were both inactivated. Representative images are shown for SA-β-GAL (blue), EGFP and 4,6-diamidino-2-phenylindole (DAPI) staining of DNA. Scale bars: 20 μm.

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