Figure 2 | Oncogene

Figure 2

From: Using a novel computational drug-repositioning approach (DrugPredict) to rapidly identify potent drug candidates for cancer treatment

Figure 2

DrugPredict ranked Non-steroidal anti-inflammatory (NSAID) significantly high. (a) Among a total of 6996 prioritized chemicals (including 1096 FDA-approved drugs), the 15 FDA-approved EOC drugs had a median ranking of 1.34% and mean ranking of 6.44% (b) Among a total of 882 fourth-level drug classes, 31 classes of drugs ranked significantly higher than random expectation. As expected, anticancer drugs (platinum compounds, pyrimidine analogs and other antineoplastic agents) ranked highest and anti-inflammatories were third highest. (c) List of the highly ranked NSAIDs reveal that celecoxib, nimesulide and indomethacin are the top 3.

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