Figure 1
From: FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis
FAM49B expression in PDAC and its correlation with LN invasion (a) Representative sections of tumors showing positive and negative immunostaining for FAM49B. The scale bars represent a 100-μm inset, × 600 magnification. (b) LN metastasis percentage in PDAC patients with positive and negative FAM49B expression. (c) Comparison of the proportions of a total of 89 patients with positive (n=23) and negative (n=65) FAM49B expression and positive lymph nodes. The results were analyzed with the Mann–Whitney U-test. (d) Representative sections of different grading derived from the PDAC GEM mouse models (LSL-KrasG12D/+, Pdx-1-Cre (KC); LSL- KrasG12D/+, LSL-Tp53R172H/+ and Pdx-1-Cre (KPC)) at different ages 3, 6, 9 and 12 months (n=8/age). The scale bar represents 100-μm.
