Figure 1
AR cistrome is retained in VCS2 cells versus VCaP cells. (a) VCaP and VCS2 cells in androgen-deprived medium were treated with 10 nM of DHT for 4 h, followed by AR ChIP-Seq. High confident peaks were identified using MACS (P-value<10−15). Overlap of AR ChIP-seq between VCaP and VCS2 cells was shown. (b–d) Average AR-binding intensity histogram (left panel) or heatmap (middle panel), or most enriched binding motifs (right panel) in (b) overlapping sites versus (c) VCaP preferred or (d) VCS2 preferred sites.
