Table 1 List of lipid biosynthetic genes that are androgen-stimulated and harbor adjacent AR-binding sites

From: Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer

Assesion

Gene ID

VCS2 (fold-change)

VCaP (fold-change)

AR-binding (VCS2 and VCaP)

NM_000533

PLP1

7.1

5.1

++

NM_014324

AMACR

5.0

1.9

++

NM_203372

ACSL3

4.4

4.2

++

NM_006745

SC4MOL

4.3

2.9

+

NM_005518

HMGCS2

4.1

2.2

++

NM_004508

IDI1

3.9

2.7

+

NM_004104

FASN

3.7

1.4

+

NM_005063

SCD

3.6

1.5

+

NM_024930

ELOVL7

3.5

2.0

++

NM_138799

MBOAT2

3.4

2.5

++

NM_005476

GNE

3.4

3.6

++

NM_000499

CYP1A1

3.2

0.6

+

NM_006918

SC5D

3.2

2.2

++

NM_015922

NSDHL

3.1

2.5

++

NM_018638

ETNK1

3.1

2.0

+

NM_002130

HMGCS1

2.9

1.1

+

NM_006579

EBP

2.9

2.1

N/A

NM_013402

FADS1

2.6

1.6

+

NM_018677

ACSS2

2.5

1.5

+

NM_002340

LSS

2.4

1.4

++

NM_018946

NANS

2.4

2.7

+

NM_002004

FDPS

2.4

1.5

+

NM_018324

OLAH

2.3

1.2

+

NM_001277

CHKA

2.2

1.1

++

NM_001360

DHCR7

2.2

1.7

++

NM_014762

DHCR24

2.2

2.9

++

NM_005768

LPCAT3

2.1

2.0

+

NM_018973

DPM3

2.1

1.6

N/A

NM_018686

CMAS

2.1

1.3

++

NM_001263

CDS1

2.0

2.1

+

NM_021814

ELOVL5

2.0

1.9

+

NM_021727

FADS3

2.0

1.5

N/A

  1. Integrated analysis of ChIP-seq of AR and gene expression in VCaP and VCS2 cells identified 32 direct AR-activated genes that mediate lipid synthesis pathways. ('++' indicates the AR-binding sites identified using P-value<10−15, while '+' indicates the AR-binding sites using P-value<10−5).
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