Figure 7
From: Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia
BFA and EHT disrupt a glioma stem-like cell hypoxia signature associated with poor survival. (a) Heat map representation of the expression levels of the 19 genes conforming the glioma stem-like cell hypoxia signature in TSC1 cells treated with either DMSO, BFA (0.1 μM), or EHT-1864 (1 μM) grown in hypoxia or normoxia (16 h) as indicated in the figure. (b) Pie charts describing the Gene Ontology protein classes of the genes in a. (c) Pie charts describing the Gene Ontology pathways of the genes in a. (d) Kaplan–Meier survival curves comparing GBM patients with high hypoxia signature scores (H) and GBM patients with low hypoxia signature scores (L). Log-rank test comparing these survival curves has a P-value of 0.0109.
