Figure 2 | Oncogene

Figure 2

From: Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome

Figure 2

Survival and weights of Cdc73+/+ and conventional Cdc73+/− knockout mice. (a) Survival of Cdc73+/+and Cdc73+/− mice (data for male and female mice combined) over 18 months. Kaplan–Meier analysis revealed significantly lower survival in Cdc73+/− mice when compared to Cdc73+/+ mice (80 versus 90%, Log-rank Mantel Cox test, P<0.05). Moreover the reduced survival in the Cdc73+/− mice was observed from 15 months of age (*P<0.05, Fisher’s exact test). (b) Kaplan–Meier analysis showed that Cdc73+/− males had significantly reduced survival than Cdc73+/− females (Log-rank Mantel Cox test, P<0.005), which was observed from the age of 7 months (*P<0.05, †P<0.01, Fisher’s exact test). (c) Kaplan–Meier analysis showing that survival of male and female Cdc73+/+ mice was similar. Moreover, the survival of Cdc73+/+ male mice did not differ significantly (P=0.094) from that of Cdc73+/− male mice (see above). (d) Bodyweights at 18 months of age of Cdc73+/+and Cdc73+/− mice, showing that the mean bodyweights of Cdc73+/+and Cdc73+/− males, and of Cdc73+/+and Cdc73+/− females were similar.

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