Figure 6

PLAU expression is associated with poor prognosis following pancreatectomy. Hazard ratio (a) and overall survival (b) in relation to PLAU mRNA expression (log scale) for a cohort of patients with resected PDAC (n=141). Increasing PLAU expression was significantly associated with poor prognosis following pancreatectomy (Cox model coefficient 0.387; likelihood ratio P=1.9e-4). Standard error of the fit is shown as a light blue band, and the distribution of PLAU expression in the cohort as a grey density distribution. 10th, 50th and 90th percentiles of the PLAU expression distribution are indicated by vertical green, blue, and orange lines, respectively. The Cox model predicted survival curves for these three percentiles of PLAU expression are further illustrated in (b).