Figure 1
From: GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness
GATA3 is overexpressed in HNSCC and high GATA3 expression is associated with poor survivals. (a) GATA3 mRNA is overexpressed in HNSCC. GATA3 mRNA levels are higher in HNSCC (n=41) compared with normal oral mucosa (n=13). The data are retrieved from Ginos Head-Neck in the Oncomine database (https://www.oncomine.org). (b) Western blot analysis of GATA3 expression in paired HNSCC tumours (T) and adjacent non-tumour mucosa tissues (N) from 12 patients. Left: Western blots showing GATA3 expression and GAPDH control. Right: GATA3 expression was quantified and analysed by paired Student’s t-test. **P<0.01. (c) Representative images of immunohistochemistry of GATA3 in paired adjacent non-tumour mucosa (N) and tumour tissues (T) from HNSCC patients (n=15). Scale bars, 50 μm. (d) Scoring of immunohistochemistry of GATA3 in HNSCC tumour tissues. The intensity of GATA3 staining is scored from 0 to 3 and grouped into low (score=0, 1) and high (score=2, 3) expression. (e) Kaplan–Meier survival analysis. Patients with follow-up period over 18 months are included (n=144). Left and right panels indicate disease-free and overall survivals of patients with low and high GATA3 expression, respectively.
