Figure 1

Upregulation of pre-45s rRNA in CRC patients. (a) Pre-45s rRNA was upregulated in tumor tissues obtained from CRC patients in Hong Kong cohort (P<0.0001, n=52). (b) The average relative expression of pre-45s rRNA in both adjacent normal (0.375±0.079) and tumor tissues (6.602±0.563). (c) The expression levels of pre-45s rRNA in tumor tissues from the patients at TNM I and II were compared with that from patients at TNM III and IV (P=0.867). (d) Pre-45s rRNA was upregulated in tumor tissues obtained from CRC patients in Zhejiang cohort. The expression level of pre-45s rRNA in paired adjacent normal and tumor tissues was compared (P<0.0001, n=28). (e) The average relative expression of pre-45s rRNA in adjacent normal (1.151±0.068) and tumor tissues (6.591±0.465). (f) The expression levels of pre-45s rRNA in tumor tissues from the patients at TNM I and II were compared with that from patients at TNM III and IV (P=0.037). β-Actin was used as an internal control for real-time PCR. Data are expressed as mean±s.d.