Table 4 Multivaried Cox regression analysis of the relationship between survival and DNA replication gene expression by taking into account age, sex, treatment (in three categories: none/chemotherapy/chemotherapy and radiotherapy), T classification (two categories: T0 or T1/T2 or T3), KI67 and PCNA clinical markers
T/N (terciles) | Overall survival | Disease-free survival | Relapse-free survival | ||||||
|---|---|---|---|---|---|---|---|---|---|
HR | (95% CI) | P-value | HR | (95% CI) | P-value | HR | (95% CI) | P-value | |
POLQ | |||||||||
0.70–3.34 (ref) | 1.00 | 1.00 | 1.00 | ||||||
3.36–6.31 | 4.59 | (0.56–37.69) | 0.16 | 1.07 | (0.35–3.29) | 0.90 | 0.93 | (0.27–3.15) | 0.90 |
6.42–86.70 | 36.31 | (2.55–517.38) | 0.008 | 1.57 | (0.40–6.18) | 0.51 | 0.94 | (0.20–4.41) | 0.94 |
PLK1 | |||||||||
0.68–6.28 (ref) | 1.00 | 1.00 | 1.00 | ||||||
6.31–14.12 | 4.43 | (0.50–39.56) | 0.18 | 3.10 | (0.78–12.32) | 0.11 | 3.26 | (0.73–14.53) | 0.12 |
14.13–74.19 | 23.49 | (1.91–288.38) | 0.01 | 11.14 | (2.35–52.75) | 0.002 | 11.11 | (1.97–62.70) | 0.006 |
RAD51 | |||||||||
0.70–2.40 (ref) | 1.00 | 1.00 | 1.00 | ||||||
2.48–4.40 | 0.72 | (0.11–4.74) | 0.73 | 0.98 | (0.31–3.13) | 0.98 | 1.08 | (0.30–3.98) | 0.90 |
4.46–19.65 | 2.94 | (0.51–16.84) | 0.23 | 3.44 | (1.00–11.83) | 0.05 | 4.00 | (0.96–16.68) | 0.06 |
CLASPIN | |||||||||
0.74–3.27 (ref) | 1.00 | 1.00 | 1.00 | ||||||
3.39–6.15 | 18.44 | (1.52–223.05) | 0.02 | 4.68 | (1.51–14.55) | 0.008 | 4.23 | (1.23–14.56) | 0.02 |
6.25–31.81 | 18.50 | (1.28–267.42) | 0.03 | 4.93 | (1.50–16.17) | 0.008 | 4.73 | (1.30–17.25) | 0.02 |
CDC6 | |||||||||
0.75–4.47 (ref) | 1.00 | 1.00 | 1.00 | ||||||
4.55–9.62 | 5.77 | (0.97–34.29) | 0.05 | 1.25 | (0.44–3.56) | 0.67 | 0.98 | (0.30–3.23) | 0.97 |
10.08–29.65 | 20.65 | (1.54–275.91) | 0.02 | 2.25 | (0.46–10.92) | 0.31 | 2.34 | (0.38–14.33) | 0.36 |
