Figure 6
From: MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma
Subcutaneous administration of miR-203 mimics reduces BCC-like lesions in mice. (a) Experimental setup and timeline of the microRNA delivery experiments in the K5tTA/TREGLI1 mice. miRIDIAN miR-203 mimics (miR-203) or control nontargeting miRNA (Ctr) were delivered by subcutaneous injections. (b) Immunostaining of BCC-like lesions for SOX9, a general marker of BCC. Arrowheads indicate BCC-like lesions with SOX9-positive cell clusters. (c) Immunostaining of BCC-like lesions for the miR-203 targets c-JUN and p63 reveals decreased expression after delivery of miR-203 mimics.
