Figure 7
From: MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma
A simplified model of the interactions of miR-203, its regulators and targets in the context of BCC. The balance between miR-203 and its targets in undifferentiated cells can be shifted toward differentiation (under physiological conditions) and toward transformation (in BCC) by calcium (Ca2+)/protein kinase C (PKC) or Hedgehog (HH) signaling, respectively. The autoregulatory loop between c-JUN and miR-203 stabilizes the phenotype of cells once differentiation has been initiated, while lack of its upregulation allows sustaining an undifferentiated state with high proliferative capacity in BCC.
