Figure 1
From: More targets, more pathways and more clues for mutant p53
Number of genes (Log10) upregulated (black bars) and downregulated (white bars) following in vitro studies where a mutant form of p53 is overexpressed. Only few codons were assayed and for each mutation it is shown that the number of genes going overexpressed is approximately similar to those downregulated. The missense mutations falling within the codon 248 (R248Q and R248W) were considered as a unique one, in order to empower the study.
