Table 3 List of genes consistently downregulated where at least three independent mutations were assayed

From: More targets, more pathways and more clues for mutant p53

ABAT

C15orf41

COBL

EDNRB

GABARAPL1

GTPBP2

KIAA1211

MARVELD2

P9

PSA

SHC4

TBXA2R

VCAN

ABCA12

C16orf5

COL18A1

EFS

GAD1

H19

KIAA1324

MCC

PADI3

PSEN2

SHROOM2

TEAD3

VSNL1

ABCG1

C17orf103

COL2A1

EGR2

GADD45A

HAGH

KIAA1751

MDFIC

PAK6

PSTPIP2

SI

TFAP2E

WDR8

ABHD15

C19orf59

CPE

ENC1

GAGEB1

HES2

KITLG

MDM2

PALMD

PTGES

SLC2A13

TGFBR1

WFDC5

ABHD4

C1orf187

CPN2

EPB49

GALE

HHATL

KLRK1

MEF2A

PARD6G

PTPN22

SLC2A8

TINAGL1

WNT5A

ABHD6

C2orf3

CRISPLD2

EPHB4

GAMT

HIC2

KREMEN2

MGC16703

PARP10

PVRL4

SLC2A9

TINP1

WWP1

ABTB2

C4A

CRYAB

EPPK1

GATA3

HIST1H2AE

KRT78

MGC4248

PARP14

PYHIN1

SLC35D1

TLR3

XLalphas

ACPP

C4orf18

CSNK1G1

ETNK1

GCH1

HLA-DMB

KRTAP2-1

MIB2

PCBP4

RALGDS

SLC35E4

TM7SF3

YPEL3

AHSA2

C5orf4

CST1

ETV7

GCLC

HOXC13

KSR

MICALL2

PCLO

RASAL1

SLC39A8

TMEM144

ZBTB1

AIFM2

C6orf204

CST11

F2RL2

GDAP1L1

HOXD10

LAMP3

MIR

PDE3A

RASGEF1B

SLC4A11

TMEM27

ZMAT3

AK1

C7orf10

CTSH

FAM105A

GDF15

HSDL2

LCE1B

MLF2

PDE4C

RASSF6

SLC4A4

TMEM63B

ZNF197

AKR1B10

C7orf57

CYFIP2

FAM134B

GDF9

HSPA5BP1

LDLRAP1

MME

PDE4D

RDH10

SLC9A1

TMG4

ZNF236

ALDH7A1

C9orf100

CYLC1

FAM13C

GGT1

HTR2A

LHX3

MPZL2

PENK

RET

SLC9A3R1

TMTC3

ZNF385A

AMACR

C9orf98

CYP2C9

FAM43A

GGT6

IDUA

LIN54

MRAS

PERP

retII

SLCO2B1

TNFRSF10B

ZNF441

ANK1

CABC1

CYP2S1

FAM46C

GH2

IFIT3

LOC132671

MRPL44

PF4V1

RGS12

SMARCD3

TNFRSF14

ZNF492

ANO4

CABYR

CYP3A7

FAM69B

GHR

IFITM1

LOC203274

MSX1

PGF

RHOD

SOM

TNP2

ZNF746

APAF1

CACNA2D2

D4S234E

FAM82A1

GJC1

IL24

LOC283585

MT1G

PLA2G2A

RNASE7

SORBS1

TNRC6C

ZNF786

APOBEC3C

CALML3

DDB2

FAM87A

GLS

IL2RB

LOC284837

MTMR6

PLAC8

RNF128

SORL1

TP53I11

 

ARAP1

CAPN1

DDC

FBXO2

GLS2

INPP1

LOC286434

MYO6

PLAT

RNF144B

SPAG1

TP53I3

 

ARG1

CARD18

DFNB31

FBXO22

GM2A

INPP5D

LOC348938

MYO7A

PLEK

RNF4

SPN

TP53INP1

 

ARHGAP6

CASP6

DGKZ

FGF1

GNA11

ISG15

LOC80154

NADSYN1

PLXNB3

RPL36

SSB2

TP53TG1

 

ARHGEF3

CBFA2T3

DHRS2

FITM2

GNA14

ISYNA1

LRDD

NCRNA00085

PMAIP1

RPS27L

STAR

TP73

 

ASPA

CCNA1

DISP1

FLJ14312

GNG2

ITFG1

LRP10

NEFL

PODXL

RPS6KA1

STARD5

TRAF4

 

ATP11B

CCT6B

DKK2

FLJ32065

GPC1

KAT2B

LTB4R

NHLH2

POLH

RRM2B

STAT4

TREM2

 

BCHE

CDH10

DMRTC1

FLJ36336

GPR126

KCNB1

LUM

NIFU

POMZP3

RTN1

STOX2

TRIM11

 

BCL11B

CDKN1A

DNAJC18

FLJ40773

GPR137B

KCNC4

MAB21L1

NLRP1

POU3F1

SAA2

SULF2

TRIM2

 

BDKRB1

CDKN1C

DNAJC21

FLNC

GPR155

KCNJ12

MAD1L1

NOTCH1

PPM1F

SAC3D1

SYK

TRIM22

 

BDNF

CEACAM1

DPYSL4

FMN1

GPR56

KIAA0247

MAEL

NOTCH3

PPP2R2B

SCN3B

SYNC

TRIM3

 

BLNK

CES2

DSG3

FREQ

GPR87

KIAA0284

MAFB

NRCAM

PPP2R2C

SCNN1G

SYTL2

TSGA10

 

BTF3L3

CLCA2

DUOX1

FRMD8

GRAMD2

KIAA1026

MAGEA4

NRP2

PRKX

SEC14L5

TAF3

TSPAN14

 

BTG2

CLDN19

DUSP13

FXYD2

GREB1

KIAA1052

MAP2K3

OIP106

PRKY

SERPINB5

TAGLN

TSPY1

 

C13orf31

CNNM4

EDAR

G6PC

GRN

KIAA1199

MAPK13

OTP

PRRX1

SESN1

TAP1

ULBP2

 
  1. The listed genes are reproducibly deregulated irrespectively on the mutated codon. Note that all the assayed mutations fall within the p53 DNA-binding domain. Bolded genes are in common with the functional assay proposed by Riley et al.3 Underlined are genes for which a high-confidence p53 occupancy sites had been mapped.