Table 5 The tool DAVID groups cluster of genes into biological pathways

From: More targets, more pathways and more clues for mutant p53

Category

Term

Count

%

P-value

Benjamini

KEGG_PATHWAY

p53 signaling pathway

26

1.9

8.6 × 10−8

1.6 × 10−5

KEGG_PATHWAY

Metabolism of xenobiotics by cytochrome P450

19

1.4

1.3 × 10−4

7.9 × 10−3

KEGG_PATHWAY

Progesterone-mediated oocyte maturation

23

1.7

3.2 × 10−4

0.015

KEGG_PATHWAY

Ascorbate and aldarate metabolism

9

0.7

3.5 × 10−4

0.013

KEGG_PATHWAY

Alanine, aspartate and glutamate metabolism

12

0.9

5.5 × 10−4

0.017

KEGG_PATHWAY

Cell cycle

28

2

1.3 × 10−3

0.029

KEGG_PATHWAY

Beta-alanine metabolism

9

0.7

2.7 × 10−3

0.052

KEGG_PATHWAY

Arginine and proline metabolism

15

1.1

2.8 × 10−3

0.05

  1. The p53 signaling pathway and pathways related to the control of the cell cycle are deregulated, as expected (analysis carried out including all 1846 genes collected among all the published studies).