Figure 4
From: A novel orthotopic mouse model of head and neck cancer and lymph node metastasis
IPA analysis of functional gene networks and signaling pathways. (a) Core analysis of the signaling pathways in the USC-HN3-GFP and USC-HN3-GFP-G2 cell lines. Green indicates under expression and red overexpression. The majority of the following gene networks were overexpressed in the USC-HN3-GFP-G2 cell line as compared with the USC-HN3-GFP-G1 cell lines: ALDH1A3 (A1, A2), OCT-4 (A3, A4), TRIM-29 (A5, A6), MMP-7 (A7, A8), CAV-1 (A9, A10), and TLR-4 (A11, A12). (b) IPA core analysis of functional networks demonstrating progressive upregulation of ‘cellular growth and proliferation genes’, ‘tumor morphology genes’, ‘cellular development genes’, ‘cell death and survival genes’ and ‘cell movement genes’ in the USC-HN3-GFP-G1 and USC-HN3-GFP-G2 cell lines as compared with parental USC-HN3-GFP cell line. ‘Cell morphology genes’ were overexpressed in both the cell lines, but there was less overexpression in the USC-HN3-GFP-G2 cell line as compared with USC-HN3-GFP-G1 cell line. Light blue indicates USC-HN3-GFP-G1 vs USC-HN3-GFP functional network gene expression values, and dark blue indicates the USC-HN3-GFP-G2 vs USC-HN3-GFP functional network gene expression values.
