Figure 2 | Oncogenesis

Figure 2

From: Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

Figure 2

Network analysis of the aggressiveness gene list. (a) Ingenuity Pathway Analysis was performed using direct interactions on the 206 genes in the aggressiveness gene list (red is overexpressed and green is underexpressed). One network of high direct interactions was identified. (b) The genes in the network in A were investigated for their correlation with the aggressiveness score and overall survival (Supplementary Table 2), and eight genes (MAPT, MYB, MELK, MCM10, CENPA, EXO1, TTK and KIF2C) with the highest correlation were still connected in a direct interaction network. (c) The overall survival of patients in the METABRIC data set was analyzed according to the score from the 8 genes in C (upper row: by quartiles; lower row: by median) in all patients, non-TNBC patients and in patients with ER+ Grade 2 tumors.

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