Table 1 Univariate and multivariate survival analysis of the aggressiveness score in the METABRIC data set

From: Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

 

Univariate Cox proportional hazards model

Multivariate Cox proportional hazards model (stepwise)

 

HR (95% CI)

P-value

HR (95% CI)

P-value

206-gene score (high, low)

1.6173 (1.4174–1.8454)

<0.0001

1.5188 (1.3227–1.7440)

<0.0001

8-gene score (high, low)

1.5853 (1.2883–1.8103)

<0.0001

1.4760 (1.2198–1.6344)

<0.0001

Lymph node (+, −)

1.8594 (1.6289–2.1224)

<0.0001

1.6807 (1.4610–1.9334)

<0.0001

Tumor size (T1, T2, T3)

1.4354 (1.2813–1.6080)

<0.0001

1.3666 (1.1642–1.6041)

0.0001

HER2 status (+, −)

1.4565 (1.2537–1.6920)

<0.0001

1.1983 (1.0183–1.4101)

0.0302

Tumor grade (1, 2, 3)

1.3500 (1.2095–1.5067)

<0.0001

NS

NS

Ki67 (+, −)

1.4184 (1.2399–1.6226)

<0.0001

NS

NS

MammaPrint (high, low)

1.3320 (1.1669–1.5204)

<0.0001

NS

NS

CIN4 (high, low)

1.5310 (1.3413–1.7476)

<0.0001

NS

NS

CIN75 (high, low)

1.5004 (1.3132–1.7143)

<0.0001

NS

NS

Cell cycle (high, low)

1.5018 (1.3145–1.7158)

<0.0001

NS

NS

ER status (+, −)

1.3016 (1.1167–1.5170)

0.0008

NS

NS

OncotypeDx (L, I, H)

1.2672 (1.0909–1.4720)

0.0021

NS

NS

Treatment (yes, no)

1.1646 (0.9753–1.2639)

0.0939

  

Age (<40, >40)

1.1235 (0.8480–1.4886)

0.4196

  
  1. Abbreviations: CI, confidence interval; ER, estrogen receptor; HR, hazard ratio; METABRIC, Molecular Taxonomy of Breast Cancer International Consortium; NS, not significant.
  2. OncoTypeDx scores are low (L,<18), intermediate (I, 18–31), high (H>31). All variables were included in the multivariate Cox proportional hazards model analysis, and by stepwise model only significant covariants were included in the final analysis shown in Table.
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