Table 2 Correlation of TTK mRNA level and clinico-pathological indicators in the METABRIC data set
Comparison | TTK low | TTK high | χ2 |
|---|---|---|---|
Tumor size | |||
<2 cm | 346 (18%) | 280 (14%) | P<1.0E−6 |
>2 cm <5 cm | 509 (26%) | 685 (35%) | P=3.2E−5 |
>5 cm | 60 (3%) | 92 (5%) | P=1.25E−2 |
Tumor Grade | |||
Grade 1 | 137 (7%) | 33 (2%) | P<1.0E−6 |
Grade 2 | 479 (25%) | 296 (16%) | P<1.0E−6 |
Grade 3 | 251 (13%) | 706 (37%) | P<1.0E−6 |
Ki67 expression | |||
Low | 826 (39%) | 242 (11%) | |
High | 237 (11%) | 831 (39%) | P<1.0E−6 |
Immunohistochemical subtypes | |||
ER-negative | 71 (4%) | 369 (19%) | P<1.0E−6 |
ER-positive | 827 (42%) | 681 (35%) | |
PR-negative | 306 (15%) | 637 (32%) | P<1.0E−6 |
PR-positive | 617 (31%) | 432 (22%) | |
HER2-negative | 802 (40%) | 744 (37%) | |
HER2-positive | 118 (6%) | 323 (16%) | P<1.0E−6 |
non-TNBC | 885 (45%) | 840 (43%) | |
Triple negative (TNBC) | 29 (1%) | 221 (11%) | P<1.0E−6 |
Intrinsic subtypes | |||
Luminal A | 552 (28%) | 169 (9%) | P<1.0E−6 |
Luminal B | 142 (7%) | 350 (18%) | P<1.0E−6 |
HER2-enriched | 40 (2%) | 200 (10%) | P<1.0E−6 |
Normal-like | 161 (8%) | 41 (2%) | P<1.0E−6 |
Basal-like | 26 (1%) | 305 (15%) | P<1.0E−6 |
Age (years) | |||
<50 | 167 (8%) | 259 (13%) | P=8.68E−4 |
50–74 | 485 (24%) | 549 (27%) | NS |
75–100 | 282 (14%) | 253 (13%) | NS |
TP53 mutation | |||
Wild-type | 390 (48%) | 331 (40%) | |
Mutant | 14 (2%) | 85 (10%) | P<1.0E−6 |
