Figure 5 | Oncogenesis

Figure 5

From: DNA damage signaling guards against perturbation of cyclin D1 expression triggered by low-dose long-term fractionated radiation

Figure 5

AKT activation at 0, 14 and 31 days after long-term FR. (a) AKT phosphorylation on Ser473 (P-AKTSer473, active AKT) by FR exposure in AT5BIVA and AT5BIVA/ATM-wt cells (upper panel) and in GM7166 and GM7166/NBS1-wt cells (lower panel). (b) PP2A activity of un-irradiated control and 31 days of FR (0.05 Gy/fraction) in AT5BIVA and AT5BIVA/ATM-wt cells. Cell lysates were collected at 24 h after the last FR. Asterisks indicate a significant decrease in PP2A activity compared with un-irradiated control cells.

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