Figure 4
APRIL serum levels associate to advanced disease features and are prognostic in rectal cancer patients. High APRIL levels in serum of rectal cancer patients are associated with reduced overall survival. (a) APRIL is highly expressed in metastatic stage IV patients. Bee swarm representation of APRIL expression in the different stages of rectal cancer patients. (b) Kaplan–Meier analysis of overall survival in 209 rectal patients grouped according to their APRIL serum level as high and low (using median as cutoff). Patients with high APRIL levels had a significantly lower overall survival (Log-rank test).
