Table 4 Cox proportional hazards regression model

From: Circulating APRIL levels are correlated with advanced disease and prognosis in rectal cancer patients

Factors

HR

95%CI

P-value

Gender

 Male

1

 

0.045

 Female

0.64

0.42–0.99

 

Age

 67<

1

 

0.322

 67

1.24

0.81–1.90

 

Grade

 G1

1

 

0.745

 G2

2.05

0.28–14.86

 

 G3

2.45

0.33–18.48

 

 Gx

1.57

0.16–15.06

 

Stage

 I

1

 

9.93E−11

 II

2.43

1.21–4.88

 

 III

2.3

1.19–4.45

 

 IV

10.04

5.18–19.45

 

 Unknown

2.78

0.63–2.31

 

APRIL expression

 Low

1

 

0.009

 High

1.79

1.16–2.76

 

Lymphatic metastasis

 Negative

1

 

1.92E−05

 Positive

2.89

1.85–4.54

 

 Unknown

1.37

0.18–10.15

 

Distant metastasis

 Negative

1

 

2.66E−11

 Positive

5.75

3.52–9.41

 

 Unknown

1.61

0.39–6.65

 

APRIL expression

 Low

1

 

0.340

 High

1.25

0.79–1.99

 

Stage

 I

1

 

4.55E−09

 II

2.41

1.20–4.85

 

 III

2.26

1.17–4.37

 

 IV

9.24

4.67–18.28

 

 Unknown

2.93

0.66–12.99

 
  1. Univariate analysis for overall survival of rectal cancer patients showed that gender, stage, lymphatic metastasis, distant metastasis and APRIL levels are statistically significant prognostic factors in our study cohort. APRIL levels as prognostic factor are dependent on stage. Cox proportional hazards regression model. Bivariate analysis on APRIL expression and stage for overall survival on rectal cancer patients.