Figure 3 | Oncogenesis

Figure 3

From: The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer

Figure 3

Microarray analysis of genes regulated by FTY720 and SAHA. Gene expression in naive MCF7 cells or MCF7 cells treated with vehicle, S1P (100 nM), FTY720 (1 μM) or SAHA (1 μM) for 24 h was determined by microarray analyses. (a) Heatmap showing supervised hierarchical clustering of 713 genes differentially expressed in FTY720-treated cells compared with naive. Expression level of a given gene is indicated by red (high) and green (low). Note that not all of the genes differentially regulated by SAHA are shown. (b) Venn diagram of genes differentially regulated by FTY720 and SAHA. (c) The gene ontology (GO) Biological Process analyses of 276 common probe sets regulated by SAHA and FTY720 treatment ranked for biological processes.

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