Figure 4 | Oncogenesis

Figure 4

From: Multiple region whole-exome sequencing reveals dramatically evolving intratumor genomic heterogeneity in esophageal squamous cell carcinoma

Figure 4

Functional intratumor genomic heterogeneity in ESCC. Non-silent mutations in each tumor region (circle I) were subjected to KEGG and Interactom database search using GlueGo algorithm. The networks of pathways and biological processes (summarized in Table 1) in each tumor region are illustrated conceptually as nodes and edges (circle II). The actionable and druggable genes in each tumor region were predicted with the Drug-Gene Interaction DATABASE (http://dgidb.genome.wustl.edu/) (circle III). Left panel: PtA, right panel: PtB; M, Metastasis.

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