Figure 2
From: Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy
(a) Schematic illustration of study design. Radioactive polymeric micelles containing 177Lu were injected intratumorally, and CPA-loaded lipid nanoparticles were injected intravenously. (b) Transmission electron microscopy images of CPA- LLP (negative staining). (Reproduced with permission from You J et al. 2015). (c–f) Effect of GDC-0449 and miR-let7b on cell viability in human pancreatic cancer cell line by micelles. HPAF-II, Capan-1, T3M4 and MIAPaCa-2 cells (5000/well) were treated with micelles containing (blue bars) GDC-0449 (0, 1, 5 and 10 μM), (green bars) GDC-0449 and scrambled miRNA, (red bars) GDC-0449 and miR-let7b (10 pmol), (peach bars) miR-let7b alone, and (purple bars) blank for 48 h. Cell viability was measured by MTT assay at the end of incubation period. (Reproduced with permission from Kumar V et al. 2015).
