Figure 4
From: Uncoupling of EGFR–RAS signaling and nuclear localization of YBX1 in colorectal cancer
(a) Expression of RAS, pERK and YBX1c in Caco2 cells following KRAS induction for 30 min, 4 , 24 and 48 h. RAS and phospho-ERK1/2 are induced after 24 and 48 h following doxycycline treatment. Phospho-ERK increases strongly after 30 min and 4 h following TGFα application; EGFR is induced 48 h after U0126 treatment. W/O (1), DMSO (2), U0126 (3), aqua bidest (4), doxycycline (5), TGFα (6). (b) RAS is upregulated after 24 h and 48 h of doxycycline treatment; again no change of YBX1n. W/O (1), DMSO (2), U0126 (3), aqua bidest (4), doxycycline (5), TGFα (6).
