Figure 3 | Oncogenesis

Figure 3

From: Dietary fat overcomes the protective activity of thrombospondin-1 signaling in the ApcMin/+ model of colon cancer

Figure 3

Thrombospondin-1 regulates lipid metabolism in liver tissue of ApcMin/+ mice fed a low-fat diet or a high-fat diet. WT, Thbs1−/−, ApcMin/+ and Thbs1−/−:ApcMin/+ mice were fed a low-fat or a high-fat western diet at the time of weaning. Livers were excised and flash-frozen for metabolomics analysis. (a) Representative long-chain free fatty acid derived from dietary fat, pentadecanoic acid, that shows induction by high-fat diet (HFD) independent of genotype, (b) levels of oleate acid, representative of fatty acids that are endogenously synthesized and show genotype- and diet-dependence, (c) caproate, a short chain fatty acid that exhibits suppression by high-fat diet that is lost in Thbs1−/−:ApcMin/+ background, (d) representative hydroylated fatty acid that shows differential regulation in Thbs1−/−:ApcMin/+ versus ApcMin/+ mice, and (e) the ketone body metabolite 3-hydroxybutyrate is selectively elevated in Thbs1−/−:ApcMin/+ mice fed a low-fat diet. N=8.

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