Figure 4 | Oncogenesis

Figure 4

From: Dietary fat overcomes the protective activity of thrombospondin-1 signaling in the ApcMin/+ model of colon cancer

Figure 4

Thrombospondin-1 synergizes with dietary fat to limit liver inflammatory eicosanoid metabolism in Apc+/+ but not in ApcMin/+ mice. Eicosanoid and 1-methylnicotinamide levels were determined in liver tissue isolated from WT, Thbs1−/−, ApcMin/+ and Thbs1−/−:ApcMin/+ mice fed a low fat or a high fat western diet at the time of weaning. (a) 13- Hydroxyoctadecadienoic acid (13-HODE) and 9-hydroxyoctadecadienoic acid (9-HODE) are isobaric, and cannot be distinguished by selective ion monitoring. (b, c) 5-Hydroxyicosatetraenoic acid (5-HETE) is a metabolite of arachidonic acid produced by 5-lipoxygenase (lox), and 15-hydroxyicosatetraenoic acid (15-HETE) is produced by 15-lipoxygenase-1. (d) 12,13-Dihydroxy-9Z-octadecenoic acid (12,13-diHOME) is a cytochrome P450 epoxygenase (CYP-epoxygenase) metabolite of linoleate. (e, f) Prostaglandins E2 and F2α are bioactive prostaglandins derived from the cyclooxygenase (COX) product PGH2. (g) 1-Methylnicotinamide is an anti-inflammatory COX-dependent nicotinamide catabolite.

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