Table 3 Univariate and multivariate Cox regression analysis for the GSE39582 data set

From: Multi-omics landscapes of colorectal cancer subtypes discriminated by an individualized prognostic signature for 5-fluorouracil-based chemotherapy

Characteristics

Univariate analysis

Multivariate analysis

 

HR a (95% CI)

P-value

HR (95% CI)

P-value

6-GPS (low risk(ref)/high risk)

3.61 (2.20,5.95)

7.26E-08

3.05 (1.66,5.60)

3.36E-04

Tumor stage (II(ref)/III)

1.43 (0.83, 2.46)

2.00E-01

1.56 (0.78, 3.10)

2.09E-01

Gender (femal (ref)/male)

1.05 (0.67, 1.66)

8.30E-01

0.74 (0.42, 1.33)

3.16E-01

Age (⩽70 (ref)/>70)

1.03 (0.62, 1.71)

9.00E-01

0.78 (0.40, 1.53)

4.73E-01

Tumor location (proximal (ref)/distal)

1.38 (0.83, 2.29)

2.10E-01

1.84 (0.93, 3.67)

8.16E-02

MMR status (pMMR (ref)/dMMR)

0.80 (0.29, 2.20)

6.70E-01

1.74 (0.49, 6.23)

3.94E-01

BRAF mutation (WT (ref)/M)

0.71 (0.17, 2.93)

6.40E-01

0.62 (0.073, 5.25)

6.61E-01

KRAS mutation (WT (ref)/M)

1.26 (0.78, 2.04)

3.40E-01

1.35 (0.73, 2.50)

3.44E-01

  1. Abbreviations: dMMR, MMR-deficient; HR, hazard ratio; M, mutation; MMR, mismatch repair; pMMR, MMR-proficient; ref, reference group in calculation of HR; WT, wild-type.
  2. Bold parts indicates the Cox regression analysis results for the 5-FU-based therapy prognostic gene pair signature.
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