Figure 5
Combination of myr-p110α with p53fl/fl;KrasG12D increases metastatic potential in a myr-p110α copy number-dependent manner. The graph showing the number of tumor lesions found in the lung surface 17 days after intravenous injection of breast tumor cells with different genotypes into the tail vein of syngeneic hosts. Error bars are the mean±s.e.m. Two-tailed unpaired Student’s t-test was used for statistical analysis. ***P<0.001. In parallel, Mann–Whitney test (Wilcoxon rank-sum test) was used to reject the null hypothesis that there is no difference between groups (***Mann–Whitney U-value=0.0009). Data are representative of three independent experiments using n=8 per group with biological and technical replicates. Six- to eight-week-old syngeneic host mice were randomly assigned to generate similar numbers of subjects among groups.
