Figure 4 | Oncogenesis

Figure 4

From: Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells

Figure 4

EGFR-Axl hetero-interaction regulates the balance between gene expression for invasive and proliferative signalling in SNB-19 cells. qRT-PCR analysis of (a) TIMP1, MMP2, CD44, (b) CCND1 and (c) MMP9 genes in SNB-19 cells treated for 24 h with 50 ng/ml EGF with or without 2 μM BGB324. Also, qRT-PCR analysis of (d) TIMP1, MMP2, (e) CCND1 and (f) MMP9 genes in SNB-19 cells with small interfering RNA knockdown of TIMP1 over 3 days, in the presence of EGF (50 ng/ml) with or without Axl blockade by BGB324 (2 μm). Data are mean±s.e.m. (N=3 independent experiments); ****P<0.0001, ***P<0.001, **P<0.01, * P<0.05.

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