Figure 3 | Oncogenesis

Figure 3

From: Gain of function of mutant p53: R282W on the peak?

Figure 3

Signaling pathways associated with p53 R282W mutation. The R282W mutant suppresses the expression of KLF17 and thereby induces epithelial mesenchymal transition (EMT). This GOF mutant also induces the expression of miR-155 and promotes cell transformation and invasion. The interaction with p63 and p73 contributes to chemoresistance, and this effect also involves the induction of CYP3A4, which is a member of the cytochrome P450 enzyme responsible for the metabolism of multiple anticancer drugs.

Back to article page