Figure 7
Gene amplification or aberrant expression of FAK and c-MYC in human HGSOC primary tumors. (a) Co-amplification of FAK/PTK2 and c-Myc in HGSOC. Top panel: Differential upregulation of FAK in the primary tumors of four distinct subtypes in the TCGA cohort of HGSOC patients. Bottom panel: Statistical evaluation of the co-amplification of FAK and Myc in primary tumors among HGSOC subtypes from the TCGA patient cohort. (b) Co-upregulation of FAK and c-MYC in primary tumors of local HGSOC patient cohort (n=15). Top panel: Representative images of FAK and Myc expression from IHC analyses of consecutive sections of primary tumors. Bottom panel: Statistical assessment of the concordance of PTK2 and Myc upregulation. Scale bar: 100 ÎĽm.
