Figure 1 | Oncogenesis

Figure 1

From: Egr-1 regulates irradiation-induced autophagy through Atg4B to promote radioresistance in hepatocellular carcinoma cells

Figure 1

Egr-1 promotes radioresistance in HCC cells. (a) Egr-1 expression was rapidly induced by radiation treatment. Western blot analysis of Egr-1 expression after different doses of IR treatment. (b) Survival of cells was examined by CCK-8 assay. SMMC-7721 and HepG2 cells were infected with Ad-GFP or Ad-DN-Egr-1 followed by IR (8 Gy) treatment, **P<0.01 vs Ad-GFP group. (c, d) Suppression of Egr-1 transcription activity inhibits colony-formation abilities of HCC cells, ***P<0.001 vs Ad-GFP group. (e) Suppression of Egr-1 transcription activity enhances IR- induced apoptosis.

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