Figure 7
LZAP and p53 protein levels correlate in non-small-cell lung cancer. (a) Left: representative photomicrographs of LZAP and p53 IHC NSCLCs. (b) Quantification of IHC (primary NSCLC, n=178); high LZAP/p53 group, strong staining in >20% of tumor cells, others designated as low. The proportions of low and high p53 staining were divided based on low and high LZAP staining. P=0.0002 analyzed by 2 × 2 contingency table (Fisher’s two-tailed test). (c) Left: schematic for LZAP regulation of p53 through HDM2. When LZAP is present, it stabilizes p53. Right: LZAP loss downregulates p53 in a MDM2-dependent manner. Following DNA damage, LZAP depletion decreases wild-type p53 in normal tissues resulting in protection, while sensitizing tumor cells harboring mutant p53 to the treatment. IHC, immunohistochemistry.
