Figure 7 | Oncogenesis

Figure 7

From: MAGE-TRIM28 complex promotes the Warburg effect and hepatocellular carcinoma progression by targeting FBP1 for degradation

Figure 7

A hypothetical model depicting MAGE-TRIM28-mediated degradation of FBP1 and increased Warburg effect and cell growth in HCC cells overexpressing MAGE and TRIM28 proteins. However, this process can be inhibited by treatment of the proteasome inhibitor bortezomib and restoring the expression of FBP1 inhibits Warburg effect and blocks HCC progression.

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