Figure 3 | Oncogenesis

Figure 3

From: Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma

Figure 3

HBV DNA integration with LINE1 (L1) after 24-h exposure to HBV NL02.C. (a) Schemes showing HBx (continuous lines) integrated with LINE1 (shaded boxes) found in six independent clones (1–6). All clones demonstrated the same sequence of the head- to-tail junction. Location of the junction in Ch15 at q11.2 and in relation to HBx sequence are shown. (b) Electropherograms detailing the breaking point between HBV (continuous line) and LINE1 (dashed line). See the legend to Figure 2 for more details.

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