Figure 5 | Oncogenesis

Figure 5

From: Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma

Figure 5

HBV integration with myosin III B (Myo3B) encoding gene in HepaRG cells at 2 and 4 weeks post infection with NL01.A. (a) Schematic presentation of integration of HBx sequence (continuous lines) with Myo3B (shaded boxes) detected in five (1–5) and four (1–4) clones obtained at 2 and 4 w.p.i., respectively. Different lengths of the Myo3 sequences, HBV and Myo3B nucleotides forming the eight-bp OHJ, and location of the integration in Ch11q13.1 and within the HBx sequence are shown. (b) Electropherograms detailing nucleotides forming the junction in relation to sequences of HBV (continuous line) and Myo3B (dashed line).

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