Figure 8 | Oncogenesis

Figure 8

From: Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma

Figure 8

Schematic representation of the HBV X gene breaking points forming junctions with the human genomic sequences. Slim arrows identify breaking points which formed junctions detected in single clones, whereas bold arrows represent those identified in multiple clones. Four black circles depict HBV TATA elements. BCP, basal core promoter; DR, direct repeat region; Enh-II, HBV enhancer II region; Pg RNA, pre-genomic RNA; URR, upstream regulatory region. Numbers mark nucleotide positions according to HBV DNA GenBank X70185 sequence.

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