Table 2 HBV-human genome junctions identified after de novo infection

From: Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma

HBV inoculum/ time post infection	Total of virus–host junctions detected (no)	Integrated HBV sequence (nt. position)	Host sequence (bp length)	Chromosome number	Sequence locus	Host sequence (nt. position)	Gene	Total of virus–virus junctions detected (no)
NL01.A
1 h	4	1720–1603	17	1	q21.1	420–437	ANP32E	0
		1639–1829	18	7	q22.1	98457063–98457081	S3A-26
		1647–1720	40	10	q21.2	111339527–111339567	ANK3
		1662–1603	48	13	q33.1	102521074 102521122	FGF14
3 h	2	1645–1700	27	14	q32.3	54–27	UI	14
		1603–1624	204	14	q31.3	86038392–86038596	FLRT2/L2
24 h	4	1246–1390	20	1	p21.3	97732036–97732056	DPYD	3
		1370–1423	16	7	q36.1	60109931–60109947	RNY-1
		1603–1623	141	8	p23.1	7874512–7874653	L1
		1603–1624	204	14	q31.3	86038392–86038596	FLRT2/L2
3 d	6	1371–1390	244	10	q11.21	42599732–42599976	HSAT-II	3
		1647–1818	505	11	q13.4	71034849–71034344	L2
		1647–1818	502	11	q13.4	71034849–71034347	L2
		1647–1818	505	11	q13.4	71034849–71034344	L2
		1647–1818	544	11	q13.4	71034849–71034305	L2
		1603–1624	204	14	q31.3	86038392–86038596	FLRT2/L2
1 w	5	1647–1818	268	11	q13.4	71034849–71034581	L2	12
		1647–1818	496	11	q13.4	71034849–71034353	L2
		1647–1818	254	11	q13.4	71034849–71034595	L2
		1634–1818	302	11	q13.4	71034849–71034547	L2
		1634–1818	502	11	q13.4	71034849–71034347	L2
2 w	10	1603–1664	19	1	q31.3	194161891–194161910	eEF1AP14	7
		1623–1717	151	2	q31.1	171450967–171450816	Myo3B
		1638–1717	151	2	q31.1	171450967–171450816	Myo3B
		1645–1717	188	2	q31.1	171450967–171450779	Myo3B
		1623–1717	160	2	q31.1	171450967–171450,807	Myo3B
		1622–1717	167	2	q31.1	171450967–171450800	Myo3B
		1638–1717	220	2	q33.1	2000084860–200085080	RNU7–147 P
		1276–1389	59	2	q33.1	200085021–200085080	RNU7–147 P
		1638–1784	44	9	q22.3	99607513–99607557	ZNF782
		1642–1784	57	9	q22.3	99607513–99607570	ZNF782
4 w	11	1634–1717	188	2	q31.1	171450967–171450779	Myo3B	5
		1633–1717	188	2	q31.1	171450967–171450779	Myo3B
		1633–1717	188	2	q31.1	171450967–171450779	Myo3B
		1634–1717	188	2	q31.1	171450967–171450779	Myo3B
		1645–1784	90	9	q22.33	99607513–99607603	ZNF782
		1645–1784	90	9	q22.33	99607513–99607603	ZNF782
		1645–1784	90	9	q22.33	99607513–99607603	ZNF782
		1645–1784	90	9	q22.33	99607513–99607603	ZNF782
		1645–1784	90	9	q22.33	99607513–99607603	ZNF782
		1645–1784	90	9	q22.33	99607513–99607603	ZNF782
		1668–1808	276	10	q21.3	70434086–70434362	TET1
7 w	3	1634–1826	32	2	q37.1	235357695–235357727	RPS20P12	7
		1643–1826	35	8	p23.1	96050–96085	AC144568
		1645–1739	60	10	p11.23	28765451–28765521	WAC-AS1
NL02.C
1 h	8	1616–1659	120	11	q25	131410505–131410385	NTM	11
		1606–1659	125	11	q25	131410505–131410380	NTM
		1606–1659	125	11	q25	131410505–131410380	NTM
		1624–1659	120	11	q25	131410505–131410385	NTM
		1606–1659	113	11	q25	131410505–131410392	NTM
		1606–1659	116	11	q25	131410505–131410389	NTM
		1606–1659	135	11	q25	131410505–131410370	NTM
		1606–1659	151	11	q25	131410505–131410354	NTM
24 h	6	1645–1764	274	15	q11.2	21340909–21341183	L1	0
		1645–1764	274	15	q11.2	21340909–21341183	L1
		1645–1764	274	15	q11.2	21340909–21341183	L1
		1645–1764	274	15	q11.2	21340909–21341183	L1
		1645–1764	274	15	q11.2	21340909–21341183	L1
		1645–1764	274	15	q11.2	21340909–21341183	L1
3 d	2	1625–1606	215	8	p23.1	7441825–7442040	L1	4
		1624–1603	189	8	p23.1	7150697–7150886	L1
2 w	2	1716–1780	79	1	p2.1	148552682–148552761	NBPF25P	2
		1390–1388	208	5	q13.3	76373689–76373809	ZBED3
NL03.E
7 d	1	1641–1778	271	10	q21.3	146–417	S3A-37	2
2 w	12	1647–1826	33	16	p11.2	34456932–34456965	HSAT-II	1
		1659–1826	35	16	p11.2	34456932–34456967	HSAT-II
		1646–1826	39	16	p11.2	34456932–34456971	HSAT-II
		1647–1816	34	16	p11.2	34456932–34456966	HSAT-II
		1647–1826	34	16	p11.2	34456932–34456966	HSAT-II
		1647–1826	35	16	p11.2	34456932–34456967	HSAT-II
		1647–1826	34	16	p11.2	34456932–34456966	HSAT-II
		1647–1826	34	16	p11.2	34456932–34456966	HSAT-II
		1647–1826	34	16	p11.2	34456932–34456966	HSAT-II
		1647–1826	34	16	p11.2	34456932–34456966	HSAT-II
		1647–1826	34	16	p11.2	34456932–3445696	HSAT-II
		1647–1826	34	16	p11.2	34456932–34456966	HSAT-II

Abbreviations: AC144568, uncharacterized RNA gene; ANK3, ankyrin3; ANP32E, acidic (leucine rich) nuclear phosphoprotein 32 family, member E; DPYD, dihydropyrimidine dehydrogenase; eEF1AP14, eukaryotic elongation factor 1 ribosomal protein; FGF14, fibroblast growth factor 14; FLRT2, fibronectin leucine rich transmembrane protein; HSAT-II, human satellite II DNA; L1, long-interspersed nuclear element-1; L2, long-interspersed nuclear element-2; Myo3B, myosin III B; NTM, neurotrimin; NBPF25P, neuroblastma breakpoint family member 25 pseudogene; RNU7-147P, RNA U7 small nuclear 147 pseudogene; RNY-1, Ro-associated Y pseudogene 1; RPS20P12, ribosomal protein S20 pseudogene 12; S3A-26, ribosomal protein S3A pseudogene 26; S3A-37, ribosomal protein S3A pseudogene 37; TET1, ten-eleven translocation 1 gene; UI, unidentified sequence; WAC-AS1, WAC antisense RNA gene; ZBED3, zinc finger, BED-type containing 3; ZNF782, zinc finger protein 782.

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Table 2 HBV-human genome junctions identified after de novo infection

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