Figure 1 | Oncogenesis

Figure 1

From: Knockdown of long non-coding RNA XIST increases blood–tumor barrier permeability and inhibits glioma angiogenesis by targeting miR-137

Figure 1

XIST expression in GECs and XIST regulated BTB permeability, glioma angiogenesis, tight junction-related proteins and CXCR7 expression. (a) Relative XIST expression in ECs and GECs by real-time qPCR. Data represent mean±s.d. (n=5, each). *P<0.05 vs ECs group. (b) Effect of XIST knockdown on TEER in BTB model in vitro. (c) Effect of XIST knockdown on HRP flux in BTB model in vitro. (d) Effect of XIST knockdown on GECs proliferation. (e) Effect of XIST knockdown on GECs migration. (f) Effect of XIST knockdown on GECs tube formation. (g) Effect of XIST knockdown on expression of tight junction-related proteins by western blot assay. (h) Effect of XIST knockdown on expression of tight junction-related proteins by immunofluorescence assay. (i) Effect of XIST knockdown on expression of CXCR7 by western blot assay. Data represent mean±s.d. (n=5, each). *P<0.05 vs XIST(−)NC group, **P<0.01 vs XIST(−)NC group. Scale bar represents 30 μm.

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