Figure 6 | Oncogenesis

Figure 6

From: Knockdown of long non-coding RNA XIST increases blood–tumor barrier permeability and inhibits glioma angiogenesis by targeting miR-137

Figure 6

FOXC1 expression in GECs and FOXC1 regulated BTB permeability, glioma angiogenesis, tight junction-related proteins and CXCR7 expression. (a) Relative FOXC1 expression in ECs and GECs by real-time quantitative PCR. Data represent mean±s.d. (n=5, each). *P<0.05 vs ECs group. (b) Relative FOXC1 expression in ECs and GECs by Western blot assay. Data represent mean±s.d. (n=5, each). **P<0.01 vs ECs group. (c) Effect of FOXC1 on TEER in BTB model in vitro. (d) Effect of FOXC1 on HRP flux in BTB model in vitro. (e) Effect of FOXC1 on GECs proliferation. (f) Effect of FOXC1 on GECs migration. (g) Effect of FOXC1 on GECs tube formation. (h) Effect of FOXC1 on ZO-1 and occludin expression by western blot assay. (i) Effect of FOXC1 on ZO-1 and occludin by immunofluorescence assay. (j) Effect of FOXC1 on CXCR7 expression by western blot assay. Data represent mean±s.d. (n=5, each) *P<0.05 vs FOXC1(+)NC group, **P<0.01 vs FOXC1(+)NC group, #P<0.05 vs FOXC1(−)NC group, ##P<0.01 vs FOXC1(−)NC group. Scale bar represents 30 μm.

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