Figure 4
Protein complexes with nsSNVs in multiple subunits. (a) Mitochondrial respiratory complex II (mapped onto a homologous complex from porcine heart, PDB id 1ZOY) and the corresponding sub-network (see text). FAD-binding protein is shown in green, mutations therein in pink; iron–sulfur protein is shown in cyan, mutations therein in orange; large cytochrome binding protein is shown in magenta, mutations therein in purple; small cytochrome binding protein is shown in yellow, mutation therein in limegreen. In the sub-network, nodes correspond to individual proteins, edges depict interactions between them. (b) Sub-network corresponding to complexes of CDK6 with its inhibitors CDKN2A and CDKN2C. Stoichiometry of the complexes is not accounted for, and nodes with a single loop edge correspond to associations of multiple identical subunits. (c) Sub-network corresponding to NRas, KRas and HRas and their downstream kinase RAF1 and activity factors SOS1 and PLCE1. (d) PIK3CA-PIK3R1 complex with mutations corresponding to cancer-associated somatic nsSNVs (top) and to nsSNVs associated with non-cancer diseases (bottom), PDB id 4L1B and the PIK3CA-PIK3R1 sub-network. PIK3CA subunit is shown in green, mutations therein in magenta and purple. PIK3R1 subunit is shown in cyan, mutations therein in orange and red.
